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Facilitated transport (FT) is a term used in the field of nanoparticle toxicity to describe chemical reactions where nanoparticles pass through biological barriers, but lose their bulk properties. One of the potential benefits of FT is the enhanced therapeutic index of the targeted drug. The term was proposed in 1997.

Several mechanisms of FT were proposed in the initial work, but the main mechanism is believed to be in the interference of transport along negatively charged tissues or cell membranes, where positively charged nanoparticles are attracted to the positively charged surfaces of cell membranes. A second possible mechanism is that nanoparticles may enter the cells by endocytosis, but then later escape from the endosome and cell surface.

The correct terminology for this concept is kinetic trapping. Kinetic trap is the term frequently used in the FT literature, but it is also widely used for another phenomenon where nanoparticles attach temporarily to the cell surface. The correct terminology for this phenomenon is kinetic binding. Another example is colloid trapping, where nanoparticles become trapped in a hydrogel.


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